Grip strength and all-cause mortality and cardiovascular disease risk: a large prospective cohort study
Leong DP, et al.
High-confidence evidence from multiple solid studies
Summary
A large prospective cohort study (PURE study) following 142,861 participants across 17 countries. Grip strength was strongly inversely associated with all-cause mortality and cardiovascular mortality risk. Each 5 kg decrease in grip strength was associated with 16% higher all-cause mortality and 17% higher cardiovascular death risk, suggesting grip strength may be a superior cardiovascular risk marker than blood pressure.
Key findings
- 1
Each 5 kg decrease in grip strength was associated with 16% higher all-cause mortality and 17% higher cardiovascular death risk
- 2
Grip strength predicted cardiovascular mortality better than blood pressure
- 3
This association persisted after adjusting for age, sex, BMI, education, smoking, and physical activity
- 4
Grip strength measurement is highlighted as an important indicator of healthy aging
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