Vitamin D
A fat-soluble vitamin synthesized in the skin from sunlight. Involved in bone metabolism, immune function, and muscle function. Deficiency is common in indoor lifestyles and low-sunlight environments. Athletes show high deficiency rates, and associations with muscle strength, immunity, and bone density are well-researched.
An ingredient with growing research

Buy
(PR)The links below include affiliate links (PR).
Effects reported in research
Improved muscle strength and power in deficient individuals (confirmed with supplementation)
Maintained bone density and reduced fracture risk (effective combined with calcium)
Support for immune function (associated with lower infection risk)
Support for testosterone production (association suggested when correcting deficiency)
Dosage & timing
- 1,000–4,000 IU (25–100 μg)/day.
- Take with dietary fat for improved absorption.
- Supplementation is particularly effective when serum 25(OH)D is below 30 ng/mL.
Cautions
- •Fat-soluble, so excess accumulation is possible.
- •Long-term intake above 10,000 IU/day may cause hypercalcemia.
- •Periodic blood level monitoring is recommended.
Supporting research
Similar supplements
Caffeine
Confidence: ModerateAnhydrous caffeine
A pre-workout staple. Alongside alertness and focus, it gives a small boost to strength, power and endurance. Tolerance builds with habitual use, so timing matters.
Betaine (Trimethylglycine)
Confidence: ModerateBetaine (Trimethylglycine, TMG)
Betaine is an amino acid derivative that acts as a methyl donor involved in creatine synthesis. Multiple RCTs have reported improvements in upper-body strength and muscle power, though results for lower-body outcomes are mixed. Cardiovascular benefits via homocysteine reduction are also under investigation.
Ashwagandha
Confidence: ModerateWithania somnifera root extract
An adaptogen herb used in Ayurvedic medicine. Multiple RCTs have confirmed associations with reduced cortisol, improved sleep, and enhanced muscle strength — making it one of the better-researched natural supplements.
Last checked: