Niacinamide (Nicotinamide)
The amide form of vitamin B3, without the flushing side effect of niacin. A precursor to NAD+/NADH involved in energy metabolism, DNA repair, and cellular signaling. At high doses, shows distinct properties from niacin.
An ingredient with growing research
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Effects reported in research
Contributes to cellular energy production and DNA repair as an NAD+ precursor
Studied in dermatology for skin barrier improvement and anti-inflammatory effects
Some research suggests effects on arthritis symptoms at high doses (1,500+ mg)
Dosage & timing
- General B3 supplementation: 14–18 mg/day.
- For NAD+ support: 250–500 mg/day.
- High-dose use for skin or joints should be under medical supervision.
Cautions
- •No flushing (unlike niacin), but hepatotoxicity risk at very high doses (3+ g/day).
- •Consult a doctor for diabetes or liver disease.
Supporting research
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