Sleep and muscle recovery: endocrinological and molecular basis for a new and promising hypothesis
Dattilo M, Antunes HK, Medeiros A, Monico-Neto M, Souza HS, Lee KS, Tufik S, de Mello MT
Evidence is still building up
Summary
睡眠と筋肉回復の内分泌学的・分子生物学的メカニズムをレビュー。睡眠不足が成長ホルモン分泌の抑制、コルチゾール上昇、筋タンパク質合成の低下を引き起こすメカニズムを整理した。睡眠はサプリメントでは代替できない最重要回復因子と結論づけた。
Key findings
- 1
睡眠中（特に深睡眠）は成長ホルモン分泌のピークであり、睡眠不足はGH分泌を顕著に抑制する
- 2
睡眠制限（6時間以下）はコルチゾール（筋タンパク分解促進ホルモン）を有意に増加させる
- 3
Leproult & Van Cauter（2011, JAMA）の関連研究では、1週間の睡眠制限（5時間/夜）で若年男性のテストステロンが10〜15%低下した
- 4
筋タンパク質合成に関わるIGF-1も睡眠不足で低下し、同化作用が全面的に妨害される
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