R-Lipoic Acid
The naturally occurring active isomer of ALA. Expected to provide equivalent antioxidant and mitochondrial support at lower doses than racemic ALA. Less stable; sodium salt form (Na-RLA) is commonly available.
An ingredient with still-limited research
Buy
(PR)The links below include affiliate links (PR).
Effects reported in research
May provide antioxidant effects at lower doses than racemic ALA
Supports mitochondrial function and energy production
Insulin sensitivity improvement reported in animal studies
Dosage & timing
- 50–200 mg/day.
- May require lower doses than racemic ALA, but human data is limited.
Cautions
- •Same cautions as racemic ALA (interactions with diabetes medications, etc.).
- •Store in a cool, dark place due to low stability.
Supporting research
Similar supplements
PQQ (Pyrroloquinoline Quinone)
Confidence: LowPyrroloquinoline quinone disodium salt
A quinone compound potentially promoting mitochondrial biogenesis (new mitochondria formation). Some studies show effects on cognitive function, memory, and energy production, but human evidence remains limited.
AHCC (Active Hexose Correlated Compound)
Confidence: ModerateAHCC (alpha-glucan from mushroom mycelium)
A polysaccharide complex extracted from Basidiomycota mushroom mycelium. Multiple clinical studies examine its ability to activate NK cells and macrophages to enhance immune function, particularly in cancer treatment support and infection prevention contexts.
Alpha-Lipoic Acid (ALA)
Confidence: ModerateAlpha-lipoic acid (racemic mixture of R- and S-isomers)
A versatile antioxidant that functions in both water- and fat-soluble environments. Studied for improving insulin sensitivity, enhancing glucose uptake, and regenerating other antioxidants (glutathione, vitamins C and E).
Last checked: