Study type: Randomized controlled trialConfidence: Low

Acute Effect of Sugar-Sweetened Beverage Intake on Plasma Uric Acid (Randomized Controlled Trial)

Carran EL, White SJ, Reynolds AN, Haszard JJ, Venn BJ

Year2016

Sample sizen=41

JournalEuropean Journal of Clinical Nutrition

AuthorsCarran EL, White SJ, Reynolds AN, Haszard JJ, Venn BJ

Evidence is still limited and needs further study

Summary

An acute crossover RCT in 41 healthy adults comparing plasma uric acid after a sucrose-based commercial soft drink, a fructose beverage, and a glucose control. Both the soft drink and fructose beverage produced larger uric acid rises at 30-60 minutes than the glucose control, with the fructose beverage producing the largest rise. Notably, the sucrose-based soft drink also raised uric acid.

Source (read the original)

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DOI: 10.1038/ejcn.2016.112

Key Findings

Key findings

Key point

1
41 healthy adults consumed a sucrose-based commercial soft drink, a fructose beverage, or a glucose control (acute crossover design)
2
Plasma uric acid was 13 and 17 µmol/L higher than the glucose control at 30 and 60 minutes after the soft drink
3
The fructose beverage produced an even larger rise (22 and 23 µmol/L)
4
The sucrose-based beverage (not HFCS-specific) also raised uric acid, not just the fructose beverage

Related Research

Related research

Randomized controlled trial

Fructose- but Not Glucose-Sweetened Beverages Increase Visceral Adiposity and Decrease Insulin Sensitivity (10-Week RCT)

Journal of Clinical Investigation, 2009

A 10-week parallel-arm RCT in overweight/obese adults consuming 25% of energy requirements from either fructose- or glucose-sweetened beverages. Both groups gained similar weight, but increased visceral adiposity, elevated fasting glucose and insulin, and decreased insulin sensitivity occurred only in the fructose group — a landmark study showing that the specific sugar (fructose vs glucose) shapes metabolic outcomes.

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Last checked: 2026-07-25