Spermidine
A polyamine found in all cells. Studied for activating autophagy (cellular self-cleaning), potentially contributing to cellular health maintenance, anti-aging, and cardiovascular protection. Gaining attention in longevity research.
An ingredient with still-limited research

Buy
(PR)The links below include affiliate links (PR).
Effects reported in research
May activate autophagy for cellular waste removal and health maintenance
Small human studies suggest cardiovascular and blood pressure improvement
Studies in older adults examine effects on cognitive function and memory retention
Dosage & timing
- ~1 mg/day (supplemental).
- Dietary intake through wheat germ and fermented foods is also a viable route.
Cautions
- •Large-scale long-term human safety data is insufficient.
- •High-dose safety is not established.
- •Consult a doctor during pregnancy or breastfeeding.
- •Much research is still at the animal study stage.
Supporting research
Similar supplements
5-HTP (5-Hydroxytryptophan)
Confidence: Moderate5-Hydroxytryptophan (from Griffonia simplicifolia seeds)
A direct precursor to serotonin, converting more efficiently than tryptophan. Studied for effects on mood, sleep quality, and appetite regulation.
AHCC (Active Hexose Correlated Compound)
Confidence: ModerateAHCC (alpha-glucan from mushroom mycelium)
A polysaccharide complex extracted from Basidiomycota mushroom mycelium. Multiple clinical studies examine its ability to activate NK cells and macrophages to enhance immune function, particularly in cancer treatment support and infection prevention contexts.
Alpha-Lipoic Acid (ALA)
Confidence: ModerateAlpha-lipoic acid (racemic mixture of R- and S-isomers)
A versatile antioxidant that functions in both water- and fat-soluble environments. Studied for improving insulin sensitivity, enhancing glucose uptake, and regenerating other antioxidants (glutathione, vitamins C and E).
Last checked: