Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers
Allen J, Bradley RD
Evidence is still building up
Summary
A double-blind, placebo-controlled trial in 40 adults free of acute or chronic disease taking 500 mg of oral glutathione twice daily (1,000 mg/day) for four weeks. The primary endpoints — urinary F2-isoprostanes and 8-OHdG — did not differ from placebo, and erythrocyte total, oxidized and ratio measures of glutathione were unchanged.
Key findings
- 1
Urinary F2-isoprostanes and 8-OHdG did not differ significantly from placebo
- 2
Erythrocyte total and oxidised glutathione, and the GSH/GSSG ratio, were unchanged
- 3
One of the few RCTs to put direct oxidative-stress markers as primary endpoints — and the result was negative
- 4
The finding conflicts with the six-month trial at the same dose (Richie et al., 2015)
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GlutathioneBlood glutathione rose over six months of supplementation — 30–35% in erythrocytes, plasma and lymphocytes (Richie et al., 2015). A four-week trial at the same dose found no change (Allen & Bradley, 2011)
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